Campus Address: Science And Math Complex 373
As a cell biologist I am interested in studying two important cellular processes, cell-cycle control and nucleocytoplasmic transport. My research is particularly focused on understanding the role of sumoylation, an essential post-translational protein modification, in regulation of these two processes in eukaryotic cells. Sumoylation is characterized by covalent attachment of small ubiquitin-related modifier protein (SUMO) to hundreds of different proteins, and thereby alters these target proteins’ activity, localization, stability, and/or interaction with other proteins. SUMO modification has emerged as a general mechanism in regulation of a wide range of cellular processes, including cell division, DNA repair, gene expression, protein trafficking, stress response, and ubiquitin-dependent proteolysis. Consistent with its diverse roles in cells, SUMO modification is associated with many diseases, including cancer, diabetes, brain ischemia, cardiovascular diseases, and neurodegenerative diseases.
Current research projects
Bio 111 - Introduction to Biology
Bio 214 - Introduction to Cell Biology
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